An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus.
More details about the regions are available here.
Region | Position | Genes | Markers | Diseases |
---|---|---|---|---|
SJO 2q32.3 | chr2:190986040-191143008 | STAT4 | rs13426947 | |
SJO 3q25.33 | chr3:159907335-160086566 | IL12A | rs485497 | |
SJO 5q35.2 | chr5:173790939-174111528 | CPEB4 | rs359457 | |
SJO 5q33.3 | chr5:160397457-160540930 | PTTG1 | rs2431697 | |
SJO MHC | chr6:32350867-32717903 | HLA-DRA HLA-DQA1 HLA-DQA2 HLA-DQB1 | rs9271588 rs3135394 rs3129716 | |
SJO 6q23.3 | chr6:137552553-137804198 | TNFAIP3 | rs6933404 | |
SJO 7q32.1 | chr7:128911686-129138653 | IRF5 | rs4728142 rs17339836 | |
SJO 11q23.3 | chr11:118523399-118920441 | CXCR5 | rs4936443 |
Study ID | Title | Publication | Diseases |
---|---|---|---|
033 | Association Study | Lessard Nat. Genet., 2013-10-06 |