Overview

IDAllelesLocationGenome BuildSource
rs4675374T/Cchr2: 20393785538dbsnp146
rs4675374T/C chr2: 204802578 37dbsnp146_grch37
imm_2_204510823T/C chr2: 203937855 38ImmunoChip
imm_2_204510823T/C chr2: 204802578 37ImmunoChip
imm_2_204510823T/C chr2: 204510823 36ImmunoChip

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Historical Ids

Old Marker IDNew Marker IDCurrent Marker IDdbSNP Build
rs56704419rs4675374rs4675374130
rs56574585rs4675374rs4675374130
rs386594575rs4675374rs4675374142

Criteria

rs4675374 meets the following criteria:

Criteria Name
Details
Disease Tags
Marker is GW-Significant in a Study 
Marker is an index SNP in a Region 

Functional Information

Gene function properties for rs4675374 as derived from dbSNP:
  • in intron
  • in 5prime utr
Gene(s) at location of variation:  ICOS 

Study

Studies containing regions of association that span this marker are shown below. Please note that when making comparisons across studies, that they may vary in terms of size, genotyping platform, and exclusion criteria. If the 'Odds Ratio' is less than 1 then the region is protective (alleles are marked as blue) otherwise it is susceptible (alleles marked as red).

StudyPublicationDiseaseRegionMarkerAllelesP-valueORMAFGene(s)

Populations

Populations data from Ensembl 1000 Genome data release May 2013:

Linkage Disequilibrium Statistics

LD Search Options

Linkage disequilibrium (LD) statistics are calculated for rs4675374, using the 1000 genomes data release May 2013. Calculations are performed with the snpStats R library, covering 1Mb either side of the marker; and with the following filters applied: MAF > 0.01, call rate < 0.9, and chi-squared test for deviation from HWE > 25.