Overview

High-density genotyping study, using the Illumina ImmunoChip platform, involving 767 Alopecia areata cases and 1475 controls of Central European origin. Replication was carried out in an independent sample of 1016 cases and 1060 controls of the same origin.  A total of 146,703 SNPs were available for analysis after the QC process.  Genotyping was performed using the MassARRAY system and a Sequenom Compact MALDI-TOF device. Imputing of the HLA region was performed using SNP2HLA. FAMHAP software package was used for the association analyses. In a meta-analysis of the data from discovery and replication cohorts, three variants reached nominal significance but failed to surpass the GWAS threshold.

Study Type
Case-Control Study
Samples
GroupPhenotypePopulationCasesControlsFamiliesTrios
DiscoveryAANULL7671475--
ReplicationAANULL10161060--
Exclusion Criteria
Samples
  • Population outliers identified through PCA analysis
  • Call rate < 99%
 
SNPs
  • Call rate < 99%
  • HWE deviation p <= 1 x 10-5
  • Minor allele frequency < 0.01

Study Association

Criteria

GDXHsS00050 meets the following criteria:

Criteria Name
Details
Disease Tags
Study for a Disease 

Publications

PMIDTitleFirst AuthorJournalDisease(s)Date