Ankylosing Spondylitis

An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Curated Regions

More details about the regions are available here.

Region	Position	Genes	Markers	Diseases
AS 1q21.3	chr1:154332714-154679688	IL6R	rs4129267	AS
AS 1p36.11	chr1:24901186-24981785	RUNX3	rs6600247	AS
AS 1q32.1	chr1:200892467-201069559	KIF21B GPR25	rs41299637	AS
AS 1p31.3	chr1:67128876-67302310	IL23R	rs12141575 rs11209026	AS CRO PSO UC IBD
AS 1q23.3	chr1:161419627-161668253	FCGR2A	rs1801274	AS CRO SLE UC IBD
AS 2q11.2	chr2:101678428-102080305	IL1R2	rs2310173	AS CRO UC
AS 2q31.3	chr2:180946221-181404099	UBE2E3	rs12615545	AS CEL
AS 2p15	chr2:62238413-62420888		rs10865331 rs6759298 rs4672495	AS CRO PSO
AS 2q37.3	chr2:240619922-240712978	GPR35	rs4676410	AS
AS 5q15	chr5:96638641-97141497	ERAP2 ERAP1	rs10045403 rs2910686 rs27037 rs27434 rs30187	AS CRO
AS 5q33.3	chr5:159397971-159460964	IL12B	rs6871626	AS CRO UC IBD
AS 9q34.3	chr9:136243135-136513440	CARD9	rs1128905	AS IBD
AS 10q24.2	chr10:99508770-99570210	NKX2-3	rs11190133	AS UC
AS 10q22.3	chr10:79258505-79313758	ZMIZ1	rs1250550	AS CRO MS
AS 12p13.31	chr12:6315411-6354696	LTBR TNFRSF1A	rs1860545	AS
AS 12q24.12	chr12:111278572-112592683	SH2B3	rs11065898	AS T1D
AS 14q31.3	chr14:87865031-88175959	GPR65	rs11624293	AS CRO
AS 16p11.2	chr16:28283985-29016486	SULT1A1 IL27	rs75301646	AS CRO
AS 17q21.32	chr17:47231738-47798656	TBX21 NPEPPS TBKBP1	rs9901869	AS
AS 17q11.2	chr17:27647591-27952572	NOS2	rs2531875	AS
AS 19p13.2	chr19:10299117-10520699	TYK2	rs35164067	AS IBD
AS 21q22.2	chr21:39081110-39111851		rs2836883 rs2242944	AS CRO UC PSC
AS 21q22.3	chr21:44152485-44266077	ICOSLG CH507-9B2.1	rs7282490	AS CRO UC IBD

Curated Studies

Study ID	Title	Publication	Diseases
012	Whole Genome Association Study	Reveille Nat. Genet., 2010-01-10	AS
026	ImmunoChip	Cortes Nat. Genet., 2013-06-09	AS