IgE and Allergic Sensitization
Allergic sensitization is the outcome of a complex interplay between the allergen and the host in a given environmental context. The first barrier encountered by an allergen on its way to sensitization is the mucosal epithelial layer.
More details about the regions are available here.
| Region | Position | Genes | Markers | Diseases |
|---|---|---|---|---|
| IGE 2q12.1 | chr2:102193725-102584846 | IL1RL1 IL18R1 | rs3771175 | |
| IGE 3q28 | chr3:188351572-188421362 | LPP | rs9865818 | |
| IGE 4p14 | chr4:38740298-38905457 | TLR10 TLR1 TLR6 | rs17616434 | |
| IGE 4q27 | chr4:122041392-122644147 | ADAD1 IL2 | rs17454584 | |
| IGE 5q22.1 | chr5:110366888-111065770 | SLC25A46 | rs10056340 | |
| IGE MHC | chr6:32428165-32715547 | HLA-DQB1 | rs6906021 | |
| IGE MHC | chr6:31338643-31469528 | HLA-B MICA | rs6932730 | |
| IGE 8q24.21 | chr8:127741008-127890277 | PVT1 MYC | rs4410871 | |
| IGE 11q13.5 | chr11:76324636-76632292 | EMSY | rs2155219 | |
| IGE 12q13.3 | chr12:56904296-57164722 | STAT6 | rs1059513 |
| Study ID | Title | Publication | Diseases |
|---|---|---|---|
| 049 | Whole Genome Association Study | Bønnelykke Nat. Genet., 2013-06-30 |