Multiple Sclerosis

A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Curated Regions

More details about the regions are available here.

Region	Position	Genes	Markers	Diseases
MS 1q32.1	chr1:200892467-201069559	C1orf106	rs55838263 rs7522462	CRO MS UC IBD
MS 1q31.2	chr1:192500477-192579099	RGS1	rs2760524 rs1359062 rs1323292	CEL MS
MS 1p36.31	chr1:6276497-6504096	PLEKHG5	rs3007421	MS
MS 1p22.1	chr1:92163769-93036894	EVI5	rs41286801 rs11810217	MS
MS 1p13.1	chr1:116487687-116569937	CD58	rs1335532 rs2300747 rs6677309	MS
MS 1p12	chr1:119621680-119802828	PHGDH	rs666930	MS
MS 1p22.3	chr1:85138055-85475616	DDAH1 BCL10	rs233100 rs11587876 rs12087340	MS
MS 1p21.2	chr1:100744097-101199255	SLC30A7 RP11-421L21.2 EXTL2 VCAM1	rs7552544 rs12048904 rs11581062	MS
MS 1p36.32	chr1:2431888-2879054	MMEL1	rs4648356 rs3748817	CEL MS
MS 1q23.1	chr1:157516546-157895873	FCRL1	rs2050568	MS
MS 1q23.3	chr1:160710974-160952405	SLAMF7	rs35967351	MS
MS 2q13	chr2:111886554-112181465	MERTK	rs17174870	MS
MS 2q37.1	chr2:230185270-230371171	SP140	rs10201872 rs9989735	CRO MS
MS 2p16.1	chr2:60694033-61609638	LINC01185	rs842639	MS UC
MS 2p13.3	chr2:68308313-68631186	PLEK	rs7595037 rs7595717	MS
MS 2p21	chr2:43082854-43187750	THADA	rs12466022 rs6718520 rs2163226	MS
MS 2p23.3	chr2:24464482-25078886	CENPO	rs4665719	CRO MS
MS 2q32.3	chr2:191050989-191166501	STAT4	rs9967792	MS
MS 3p24.3	chr3:18566300-18815368		rs11719975	CRO MS
MS 3p24.1	chr3:27639513-27797643	EOMES	rs11129295 rs2371108	MS
MS 3q13.33	chr3:119384793-119581808	TIMMDC1	rs1131265 rs2293370	MS PBC
MS 3p22.3	chr3:32856713-32998085	CCR4	rs4679081	MS
MS 3q13.11	chr3:105653463-105954342	CBLB	rs9657904	MS
MS 3q25.33	chr3:159872508-160007733	IL12A	rs1014486	MS PBC
MS 3q12.3	chr3:101953037-102091610	NFKBIZ	rs771767	MS
MS 3p24.1	chr3:27999281-28088981	EOMES	rs1813375 rs170934 rs669607	MS
MS 3p13	chr3:71383457-71585992	FOXP1	rs9828629	MS
MS 3q13.33	chr3:121616614-122127985	CD86 IQCB1 SLC15A2	rs9282641 rs1920296 rs4285028 rs2255214	MS
MS 4q24	chr4:102467408-103242450	MANBA	rs228614 rs7665090	MS PBC UC
MS 4q24	chr4:105002488-105561558	TET2	rs2726518	MS
MS 5q33.3	chr5:159091760-159399302	IL12B	rs2546890	MS PBC PSO
MS 5p13.2	chr5:35795636-36035028	IL7R	rs6881706 rs6897932	MS PBC
MS 5p13.1	chr5:40286865-40626651	PTGER4	rs4613763 rs6880778	CRO MS UC IBD
MS 5q31.1	chr5:134069014-134441881	TCF7	rs756699	MS
MS 5q31.3	chr5:142033064-142260854	NDFIP1	rs371522651	MS
MS 5q35.3	chr5:177079730-177421018	RGS14	rs4075958 rs4976646	MS
MS 5q11.2	chr5:56122309-56161300	ANKRD55	rs71624119	CRO JIA MS RA
MS MHC	chr6:32371209-32714887	HLA-DQA1 HLA-DQA2 HLA-DRB1	rs3129889 rs2040406	CEL MS
MS 6q23.3	chr6:135268129-135820013	AHI1	rs11154801	MS
MS 6q23.3	chr6:137006677-137196354	IL22RA2	rs17066096	MS
MS 6q22.33	chr6:127633469-128020756	PTPRK	rs802734	CEL MS
MS 6q23.3	chr6:137552553-137981174	TNFAIP3	rs67297943 rs13192841 rs7769192	MS
MS 6p21.31	chr6:36376436-36646035	PXT1	rs941816	MS
MS 6q15	chr6:90097116-90319078	BACH2	rs72928038 rs12212193	ATD MS RA T1D
MS MHC	chr6:29866695-30096785	HLA-B	rs9260489	MS
MS 6q25.3	chr6:158897742-159120449	TAGAP	rs1738074 rs212405	CEL CRO MS T1D
MS 6p23	chr6:14691381-14736360		rs17119	CRO MS UC IBD
MS 7q36.1	chr7:149421444-149668212	ZNF767P	rs354033	MS
MS 7p22.2	chr7:3053866-3151535	CARD11	rs1843938	MS
MS 7p15.1	chr7:28080094-28222707	JAZF1	rs917116	MS
MS 7p14.1	chr7:37318708-37399609	ELMO1	rs60600003	MS
MS 7p15.2	chr7:26619513-27166372		rs706015	MS
MS 7p12.2	chr7:50212219-50325817	IKZF1	rs201847125	MS
MS 8q21.12	chr8:78501108-78839890	ZC2HC1A	rs1021156	MS
MS 8q24.21	chr8:127078717-127221075		rs2456449	MS
MS 8q24.21	chr8:128105690-128266545	MIR1208 PVT1	rs759648 rs2019960	MS
MS 8q24.21	chr8:127741008-127890277	MIR1204 PVT1 MYC	rs4410871	MS IGE
MS 9p24.1	chr9:5796779-6145022	MLANA	rs2150702	MS
MS 10p15.1	chr10:5988280-6134149	IL2RA	rs7089861 rs3118470 rs12722489 rs2104286 rs7090512	CRO MS RA T1D AA
MS 10q23.33	chr10:92439580-92742146	HHEX	rs7923837	MS
MS 10p11.22	chr10:30843546-31191775	ZNF438	rs793108	MS RA
MS 10q22.2	chr10:73639542-73945471	C10orf55	rs2688608	CRO MS
MS 10q22.3	chr10:79252314-79313758	ZMIZ1	rs1250550 rs1782645	AS CEL CRO MS IBD
MS 11q23.3	chr11:118441401-118958811	CXCR5 TREH	rs523604 rs9736016 rs533646 rs630923	CRO MS PBC IBD
MS 11q12.2	chr11:60971360-61093417	CD6 CD5	rs650258 rs34383631	MS
MS 11q13.1	chr11:64076473-64456055	PRDX5	rs694739	CRO MS T1D AA
MS 11p11.2	chr11:46326774-49110443	AGBL2	rs7120737	MS
MS 11q21	chr11:95537638-95599614		rs4409785	ATD MS RA VIT
MS 12q24.31	chr12:122875604-123523526	PITPNM2	rs7132277	MS
MS 12p13.31	chr12:6312329-6354696	TNFRSF1A	rs1800693	AS MS PBC
MS 12p13.31	chr12:9364013-9820167	CLECL1 CD69	rs11052877 rs10466829	MS
MS 12q14.1	chr12:57567711-58094884	TSFM AGAP2 METTL1	rs703842 rs12368653 rs201202118	MS
MS 12p13.31	chr12:6373620-6414083	LTBR	rs12296430	MS
MS 13q32.3	chr13:99392419-99584483	MIR548AN	rs4772201	MS
MS 14q31.3	chr14:87857711-88175959	GALC GPR65	rs74796499 rs2119704	MS
MS 14q24.3	chr14:75476220-75565163	BATF	rs2300603	MS
MS 14q32.32	chr14:102585564-102957748	TRAF3	rs12148050	MS
MS 14q24.1	chr14:68696033-68851345	ZFP36L1	rs2236262 rs4902647	MS
MS 15q26.1	chr15:90268570-90667491	IQGAP1	rs8042861	MS
MS 15q25.1	chr15:78696056-78968794	CTSH	rs59772922	MS
MS 16p11.2	chr16:29834364-30494500	MAPK3	rs7204270	MS
MS 16q22.1	chr16:68402003-68815934	CDH3	rs1886700	MS
MS 16p13.3	chr16:996471-1059435	SOX8	rs2744148	MS
MS 16q23.1	chr16:79072922-79097496	WWOX	rs12149527	MS
MS 16p13.13	chr16:10923201-11392189	RMI2 CLEC16A	rs12927355 rs4780346 rs7200786 rs12708716 rs6498184	CRO MS PBC T1D IBD
MS 16q23.2	chr16:79595363-79627600	MAF	rs7196953	MS
MS 16q24.1	chr16:85948640-85990498	IRF8	rs13333054 rs35929052	MS
MS 17q21.2	chr17:42142007-42774617	STAT3	rs9891119 rs2293152 rs4796791	CRO MS UC IBD
MS 17q12	chr17:39219977-40074859	IKZF3	rs12946510	CRO MS PBC UC IBD
MS 17q21.32	chr17:47231738-47798656	NPEPPS	rs4794058	AS MS
MS 17q23.1	chr17:59412005-59997425	VMP1 RPS6KB1	rs8070345 rs180515	CRO MS
MS 18q22.2	chr18:69831437-69902924	CD226	rs763361	MS T1D
MS 18q21.32	chr18:58650125-58836789	MALT1	rs7238078	MS
MS 19p13.2	chr19:10280033-10517872	TYK2	rs34536443	CRO JIA MS PBC PSO RA T1D IBD
MS 19p13.11	chr19:16328687-16640429	EPS15L1	rs1870071	MS
MS 19q13.33	chr19:48593054-48774825	MAMSTR	rs281380	CRO MS T1D
MS 19q13.33	chr19:49217653-49427464	DKKL1	rs8107548 rs2303759	MS
MS 19p13.11	chr19:18080811-18300992	MPV17L2 IFI30	rs11554159 rs874628	MS
MS 19p13.3	chr19:6613822-6685293	TNFSF14	rs1077667	MS
MS 19p13.2	chr19:10523588-11047358	SLC44A2	rs2288904	MS
MS 20q13.33	chr20:63568094-63857674	SLC2A4RG ZBTB46	rs6062314 rs2256814	CRO MS
MS 20q13.13	chr20:49790590-50046045	SLC9A8	rs17785991	MS
MS 20q13.2	chr20:54160302-54206301	CYP24A1	rs2248359	MS
MS 20q13.12	chr20:45903616-46163333	CD40 NCOA5	rs2425752 rs4810485	CRO MS
MS 22q11.21	chr22:21644220-22000056	MAPK1	rs2283792	MS
MS 22q13.33	chr22:50491152-50633733	ODF3B	rs140522	MS

Curated Studies

Study ID	Title	Publication	Diseases
007	Whole Genome Association Study	Sawcer Nature, 2011-08-10	MS
022	Walkthrough Test	Uslu Nat. Genet., 2014-05-25	CRO MS
030	Immunochip	Beecham Nat. Genet., 2013-09-29	MS
040	Whole Genome Association Study	Fortune Nat. Genet., 2015-06-08	CEL MS RA T1D
041	Whole Genome Association Study	Patsopoulos Ann. Neurol., 2011-12-01	MS
043	Whole Genome Association Study	Sanna Nat. Genet., 2010-05-09	MS
044	Case-Control Study	Lill Brain, 2013-06-01	MS