Psoriasis

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. Psoriatic lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region; the pathology involves an accelerated epidermopoiesis. Psoriasis is associated with increased risk for melanoma, squamous cell carcinoma, and basal cell carcinoma.

Curated Regions

More details about the regions are available here.

Region	Position	Genes	Markers	Diseases
PSO 1p36.23	chr1:8140630-8245971	SLC45A1 TNFRSF9	rs11121129	PSO
PSO 1q21.3	chr1:152564308-152813337	LCE3D LCE3B	rs6677595 rs4112788	PSO
PSO 1p36.11	chr1:24134948-24201326	IFNLR1	rs7552167	PSO
PSO 1p31.3	chr1:67128876-67302310	IL23R	rs9988642 rs11209026	AS CRO PSO UC IBD
PSO 1p36.11	chr1:24898466-24981785	RUNX3	rs7536201	AS PSO
PSO 2p15	chr2:62256286-62420888	B3GNT2	rs10865331	AS CRO PSO
PSO 2q24.2	chr2:162136981-162536251	KCNH7 IFIH1	rs17716942	PSO
PSO 2p16.1	chr2:60694033-61571694	REL LINC01185	rs62149416 rs702873	PSO
PSO 5q31.1	chr5:132447521-132799680	IL4 IL13	rs1295685	PSO
PSO 5q33.1	chr5:151035777-151110563	TNIP1	rs2233278	PSO
PSO 5q33.3	chr5:159088191-159480008	IL12B	rs12188300 rs3213094	CRO PSO
PSO 5q15	chr5:96639288-97039314	ERAP1	rs27524 rs27432	AS PSO
PSO MHC	chr6:31239202-31375450	HLA-B HLA-C	rs4406273 rs10484554	CEL CRO PSO
PSO 6q23.3	chr6:137707015-137957868	TNFAIP3	rs582757	PSO
PSO 6q21	chr6:111072574-111648145	TRAF3IP2	rs33980500 rs240993 rs458017	PSO UC
PSO 6p25.3	chr6:496761-661714	EXOC2 IRF4	rs9504361	PSO
PSO 6q25.3	chr6:158907321-159123547	TAGAP	rs2451258	CEL CRO MS PSO RA
PSO 7p14.1	chr7:37319353-37399609	ELMO1	rs2700987	PSO
PSO 9p21.1	chr9:32425912-32581661	DDX58	rs11795343	PSO
PSO 9q31.2	chr9:107981292-108105810	KLF4	rs10979182	PSO
PSO 10q22.3	chr10:79237086-79312766	ZMIZ1	rs1250546	CEL CRO PSO IBD
PSO 11q24.3	chr11:128502273-128623452	ETS1	rs3802826	PSO
PSO 11q22.3	chr11:110026038-110323530	ZC3H12C	rs4561177	PSO
PSO 12q13.3	chr12:55958153-56408728	STAT2 IL23A	rs2066819	PSO
PSO 14q13.2	chr14:34900397-35394209	NFKBIA	rs8016947	PSO
PSO 16p13.13	chr16:11198022-11372654	PRM3 SOCS1	rs367569	PBC PSO
PSO 16p11.2	chr16:30520539-31368034	FBXL19 PRSS53	rs12445568	PSO
PSO 17q11.2	chr17:27548316-27947963	NOS2	rs28998802	PSO
PSO 17q25.3	chr17:80130413-80261661	CARD14	rs11652075	PSO
PSO 17q21.2	chr17:42166716-42824441	STAT3 STAT5A PTRF STAT5B	rs963986	PSO
PSO 18q21.2	chr18:53952661-54742246	POLI STARD6 MBD2	rs545979	PSO
PSO 19p13.2	chr19:10523588-11054105	ILF3 CARM1	rs892085	PSO
PSO 19p13.2	chr19:10280033-10517872	TYK2	rs12720356 rs34536443 rs280519	CRO JIA MS PBC PSO RA T1D IBD
PSO 20q13.13	chr20:49792078-50046045	RNF114	rs1056198	PSO
PSO 22q11.21	chr22:21454896-21649639	UBE2L3	rs4821124	CEL CRO PSO

Curated Studies

Study ID	Title	Publication	Diseases
013	Whole Genome Association Study	Strange Nat. Genet., 2010-10-17	PSO
016	Immunochip	Tsoi Nat. Genet., 2012-11-11	PSO