Rheumatoid Arthritis

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Curated Regions

More details about the regions are available here.

Region	Position	Genes	Markers	Diseases
RA 1p34.3	chr1:37731957-38002404	INPP5B MTF1	rs28411352	RA
RA 1p13.2	chr1:113288123-114009223	PTPN22	rs6679677 rs2476601	ATD CRO JIA RA SLE T1D AA VIT
RA 1p36.13	chr1:17240113-17353103	PADI4	rs2240336 rs2301888	RA
RA 1q25.1	chr1:173329925-173871661		rs2105325	RA
RA 1p36.32	chr1:2431888-2879054	TNFRSF14 MMEL1	rs2843401 rs187786174	CEL MS RA
RA 1q21.3	chr1:154335188-154679688	IL6R	rs2228145	RA
RA 1p34.3	chr1:38136523-38238517	POU3F1 LINC01343	rs883220 rs12140275	RA
RA 2q32.3	chr2:190986040-191143008	STAT4	rs11889341 rs13426947	PBC RA SLE SJO
RA 2p16.1	chr2:60694033-61616575	REL	rs34695944	RA
RA 2q33.1	chr2:200781905-201640992	CASP8 CFLAR	rs6715284	RA
RA 2q33.2	chr2:203581104-203951852	CD28 CTLA4	rs11571302 rs3087243 rs1980422	ATD CEL RA T1D
RA 2q13	chr2:110225473-111045908	ACOXL	rs6732565	RA
RA 2q11.2	chr2:99918896-100425222	AFF3	rs9653442 rs11676922 rs10209110	RA T1D
RA 2p14	chr2:65170461-65489960	SPRED2	rs934734 rs1858037	RA
RA 2p23.1	chr2:30192259-30240054	LBH	rs10175798	RA
RA 3p24.1	chr3:27639513-27794554	EOMES	rs3806624	RA
RA 3p14.3	chr3:58563920-58615320	PXK	rs13315591	RA
RA 3q22.3	chr3:135890168-137099199	IL20RB	rs9826828	RA
RA 3p24.3	chr3:16837707-17112238	PLCL2	rs4452313	RA
RA 3p14.3	chr3:58099168-58544384	PXK DNASE1L3 ABHD6	rs73081554 rs35677470	RA SSC
RA 4q27	chr4:122017479-122644147	IL21 IL2	rs13119723	CEL RA
RA 4p15.2	chr4:26026565-26130530	RBPJ SMIM20	rs11933540 rs932036 rs874040	RA
RA 4p16.1	chr4:10696641-10915159	CLNK	rs13142500	RA
RA 5q21.1	chr5:102699259-103415498	C5orf30	rs26232 rs2561477	RA
RA 5q11.2	chr5:56119129-56175811	ANKRD55 IL6ST	rs6859219 rs71624119 rs7731626	CRO JIA MS RA
RA 6q15	chr6:90097116-90319078	BACH2	rs72928038	ATD MS RA T1D
RA 6p25.3	chr6:384546-467748	IRF4	rs9378815	RA
RA MHC	chr6:32371299-32727855	HLA-DRB1	rs660895 rs6457617 rs9268839	CEL RA UC
RA 6q25.3	chr6:158904430-159123547	TAGAP	rs629326 rs2451258	CEL CRO MS PSO RA
RA 6q25.1	chr6:149315830-149932104	PPIL4	rs9373594	RA
RA 6q21	chr6:106150492-106380042	ATG5	rs9372120	RA
RA 6p21.1	chr6:44257254-44326129	NFKBIE	rs2233424	RA
RA 6p21.31	chr6:36375944-36646035	ETV7	rs2234067	RA
RA 6q23.3	chr6:137568133-137966423	TNFAIP3	rs17264332 rs7752903 rs6920220	CEL RA SLE T1D UC IBD
RA 6q27	chr6:166935019-167134466	RP11-517H2.6 CCR6	rs1571878 rs59466457 rs3093023	RA
RA 7q32.1	chr7:128911686-129137466	IRF5	rs3807306 rs10488631 rs3778753	PBC RA SLE UC
RA 7q21.2	chr7:92434186-92805872	CDK6	rs4272	RA
RA 7p15.1	chr7:28080094-28222707	JAZF1	rs67250450	RA
RA 7p14.1	chr7:37323977-37400850	ELMO1	rs79758729	CEL RA
RA 8p23.1	chr8:11426026-11546260	BLK	rs2736337	RA
RA 8q21.13	chr8:80159381-80417925	TPD52	rs998731	RA
RA 8q24.21	chr8:128484980-128585383	PVT1	rs1516971	RA
RA 8q22.3	chr8:101367069-101475028	GRHL2	rs678347	RA
RA 9q33.2	chr9:120584375-121363046	TRAF1 C5	rs10985070	RA
RA 9p13.3	chr9:34648421-34996017	CCL21 CCL19	rs11574914 rs2812378 rs951005	RA
RA 10p15.1	chr10:6346109-6394072	PRKCQ	rs947474	RA
RA 10p14	chr10:8954304-9174993		rs12413578	RA
RA 10p11.22	chr10:30843546-31191775	ZNF438	rs793108	MS RA
RA 10p15.1	chr10:5988280-6132638	IL2RA	rs706778 rs2104286 rs10795791	MS RA T1D
RA 10q11.23	chr10:48760551-48932543	WDFY4	rs2671692	RA
RA 10q21.2	chr10:61937130-62395176	ARID5B RTKN2	rs12764378 rs71508903 rs6479800	RA
RA 10p14	chr10:8041925-8083759	GATA3	rs2275806 rs3824660	RA
RA 11q24.3	chr11:128558890-128692203	ETS1	rs73013527	RA
RA 11q22.3	chr11:107973474-108562579	ATM	rs138193887	RA
RA 11q12.2	chr11:61067850-61377180	CD5	rs595158	RA
RA 11q12.2	chr11:61753196-61917078	FADS2 FADS1 FADS3	rs968567	CRO RA
RA 11q21	chr11:95537638-95599614	CEP57	rs4409785	ATD MS RA VIT
RA 11q23.3	chr11:118523399-118920441	CXCR5 DDX6	rs10790268 rs4938573	CEL PBC RA
RA 12q13.2	chr12:55958153-56397446	CDK2	rs773125	RA
RA 12q24.12	chr12:111269993-112592683	PTPN11 SH2B3	rs3184504 rs10774624	CEL CRO JIA PBC RA T1D PSC VIT
RA 13q14.11	chr13:39618079-39887654	COG6	rs9603616	RA
RA 14q23.1	chr14:61437664-61536516	PRKCH	rs3783782	RA
RA 14q24.1	chr14:68090027-68492994	RAD51B	rs1950897	RA
RA 15q23	chr15:69667254-69758634	DRAIC TLE3	rs8026898	RA
RA 15q14	chr15:38522176-38665929	RASGRP1	rs8032939 rs8043085	CRO RA T1D
RA 16p13.13	chr16:11663703-11822505	TXNDC11	rs4780401	RA
RA 16q24.1	chr16:85956974-85990498	IRF8	rs13330176	RA
RA 17p13.2	chr17:5212114-5550267	C1QBP	rs72634030	RA
RA 17q12	chr17:39218393-40083963	MED1 IKZF3 CSF3	rs2872507 rs1877030 rs59716545	CRO PBC RA T1D UC IBD
RA 18p11.21	chr18:12738414-12926279	PTPN2	rs8083786	RA
RA 18q22.2	chr18:69838097-69902924	CD226	rs2469434	RA
RA 19p13.2	chr19:10280033-10517872	TYK2	rs34536443	CRO JIA MS PBC PSO RA T1D IBD
RA 19p13.2	chr19:10523588-11048849	ILF3	rs147622113	RA
RA 20q13.12	chr20:45906012-46172387	CD40	rs6032662 rs4239702	CRO RA
RA 21q22.12	chr21:35316472-35450246	RUNX1	rs9979383 rs8133843	JIA RA
RA 21q22.3	chr21:42389309-42471211	UBASH3A	rs1893592 rs11203203	CEL RA T1D VIT
RA 21q22.12	chr21:34454062-34639390	RCAN1	rs2834512	RA
RA 22q13.1	chr22:39259042-39371656	SYNGR1	rs909685	PBC RA
RA 22q11.21	chr22:21454896-21649639	YDJC UBE2L3	rs11089637	CRO RA
RA Xq28	chrX:153853745-154120938	IRAK1	rs5987194 rs13397	CEL RA
RA Xq21.1	chrX:78745152-79369242	P2RY10	rs201408742	RA

Curated Studies

Study ID	Title	Publication	Diseases
005	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls	Nature, 2007-06-07	CRO RA T1D
014	Genome-wide association study meta-analysis	Stahl Nat. Genet., 2010-05-09	RA
019	Immunochip	Eyre Nat. Genet., 2012-11-11	RA
035	Meta-analysis	Okada Nature, 2013-12-25	RA
040	Whole Genome Association Study	Fortune Nat. Genet., 2015-06-08	CEL MS RA T1D